Targeted Sequencing Bags a Rare Disease
This looks neato. One of the first papers to use the Agilent Tech to do targeted re-sequencing. I can't wait to get my hands on a PDF.
The impressive economy of this paper is that they targeted (using Agilent chips) less than 30Mb of the human genome, which is less than 1%. They also worked with very few samples; only about 30 cases of Miller Syndrome have been reported in the literature. While I've expressed some reservations about "exome sequencing", this paper does illustrate why it can be very cost effective and my objections (perhaps not made clear enough before) is more a worry about being too restricted to "exomes" and less about targeting.
More @ Omics! Omics!
Sexually Antagonistic Selection, Sexual Dimorphism, and the Resolution of Intralocus Sexual Conflict
Haven't read much on this particular topic, but given direction that my thesis is going I gotta start brushing up on the sexual selection literature. Anyway, this unusual review discusses the importance of sexual selection from an intra-locus perspective the essential idea being that in sexually dimorphic species single locus traits may be under different selective regimes depending upon the sex in which they are expressed (= sexually antagonistic selection). The authors find, with some caveats, that sexually antagonistic selection may be present in as many as 17% of species that exhibit sexual dimorphism.
- Cox R, Calsbeek R. (2009) Sexually Antagonistic Selection, Sexual Dimorphism, and the Resolution of Intralocus Sexual Conflict. American Naturalist, vol. 173 [link]
